Interferon and Host Resistance to Rauscher Virus-induced Leukemia
نویسندگان
چکیده
منابع مشابه
Cross-resistance to the transplantation of syngeneic Friend, Moloney, and Rauscher virus-induced tumors.
Immimofluorescence data are presented which confirm the previously reported cytotoxic antibody studies suggesting that Friend, Moloney, and Rauscher (FMR) virus-induced lymphomas possess similar surface antigens, not shared by Gross lymphomas. It is not known, however, whether the antigenic relationship demonstrable serologically is, or should necessarily be, demonstrable by transplantation stu...
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Hepatitis C virus (HCV) envelope glycoprotein-2 (E2) inhibits the interferon (IFN)–induced, double –stranded RNA activated protein kinase (PKR) via PKR eukaryotic initiation factor-2α phosphorylation homology domain (PePHD). Present study examined the genetic variability of the PePHD in patients receiving interferon therapy. The PePHD region from HCV genotype 1a/1b infected patients receiving I...
متن کاملSynthesis of Rauscher murine leukemia virus-specific polypeptides in vitro.
The biosynthesis of specific polypeptides directed by purified viral messenger RNA from JLS-V9 cells infected with Rauscher leukemia virus has been studied in a rabbit reticulocyte lysate. The 35S viral mRNA gives rise to two major products of 65,000 and 72,000 molecular weight. The synthesis of specific polypeptides was also investigated in lysates derived from infected cells. The main product...
متن کاملCharacterization of a p30 Fraction from Rauscher Leukemia Virus
The p30 antigen from Rauscher leukemia virus (RMuLV) was separated into two fractions by chromatography on either phosphocellulose or DEAE-cellulose. The p30-I and p30-I1 were indistinguishable immunologically or by isoelectrofocusing and gel electrophoresis. An ATPase activity was tightly associated with p30-I1 that could not be separated by ion-exchange chromatography, isoelectrofocusing, or ...
متن کاملAbsence of plasma erythropoietin in mice with anemia induced by Rauscher leukemia virus.
response to anemia induced in mice with RLV (2). The present report offers further evidence to support and extend this observation. Our previous work has involved the study of an anemia-inducing isolate of RLV obtained from BALB/c mice bearing a transplantable leukemia (3) that induces a progressive, fatal anemia with splenomegaly and hepatomegaly resulting from the accumulation of erythroblast...
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ژورنال
عنوان ژورنال: Journal of Virology
سال: 1969
ISSN: 0022-538X,1098-5514
DOI: 10.1128/jvi.3.2.99-105.1969